Comparison between LADA, Type 1 Diabetes and Type 2 Diabetes

Comparison between LADA, Type 1 Diabetes and Type 2 Diabetes

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LADA is neither classified as type 2 diabetes or type 1 diabetes but considered somewhere in between. It is a form of type 1 diabetes that has similarities and differences to both type 1 and type 2 diabetes.

1.Onset: Type 1 diabetes onsets rapidly and at a younger age than does LADA. Both LADA and type 2 onset is slow, over many months or years.

2.Family history: There is often an absence of family history of type 2 diabetes in a LADA patient’s family, but a genetic marker of HLA genes found in type 1 and LADA, but not in type 2 diabetes. LADA does not  usually affect children and is uncommon in young adults (age 25–30). It is most often diagnosed after age 35.

3.Antibodies: Persons with type 1 diabetes and LADA usually test positive for certain (same) antibodies that are not present in type 2 diabetes.

4.GAD antibodies: Persons with LADA usually test positive for GAD antibodies, whereas in type 1 diabetes these antibodies are more commonly seen in adults rather than in children.

5.Insulin sensitivity: Persons with LADA are not insulin resistant (and may be insulin sensitive) as in the case of type 2 diabetes and prediabetes.

6.Lifestyle and excess weight: Type 2 diabetes may onset as a result of a sedentary lifestyle and excess body weight (especially when excess weight is carried about the center, or in those with an “apple” shaped body).

These factors are not thought of as contributing factors to the onset of type 1 diabetes or LADA.

Persons with LADA are often normal body weight or thin and are not insulin resistant.

Persons with type 2 diabetes are often insulin resistant and overweight.

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7.Prognosis: About 80% of all persons initially diagnosed with type 2, who also have GAD antibodies, will become insulin dependent within six years.

LADA occurs slowly, but progresses towards insulin dependency.

8.Treatment: Although LADA may appear to initially respond to similar treatment (lifestyle and medications) as type 2 diabetes, it will not halt or slow the progression of beta cell destruction.

People with LADA will eventually become insulin dependent.

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